Easy Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

The aroma of spicy Cajun seasoning wafts through the kitchen as creamy sauce simmers, slowly inviting you to take a bite. This Easy Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is a delightful combination of tender chicken, al dente pasta, and a luscious, cheesy sauce that comes together in just under 30 minutes. It works wonderfully because the richness of the cream cheese and mozzarella balances the bold flavors from the Cajun seasoning.

This recipe is perfect for busy weeknights when you need a quick yet satisfying meal for the whole family. It also makes great leftovers, so feel free to prepare it in advance and store it for a delicious meal later in the week.

Why You’ll Love This Recipe

• The combination of spices adds a dynamic flavor to the dish.
• The creamy mozzarella sauce creates a comforting texture that clings to the spaghetti.
• It’s a one-pan recipe, simplifying both cooking and cleanup.
• The dish can be ready in under 30 minutes, fitting easily into a busy schedule.

What You’ll Need

Gather the following ingredients to create your delicious meal:

For the Chicken

• 1 pound boneless, skinless chicken breasts, cut into bite-sized pieces
• 2 tablespoons olive oil
• 2 tablespoons Cajun seasoning
• 1 teaspoon smoked paprika

For the Pasta

• 1 pound spaghetti

For the Sauce

• 4 tablespoons butter
• 4 cloves garlic, minced
• 1/4 cup all-purpose flour
• 3 cups whole milk
• 1 cup chicken broth
• 8 ounces cream cheese, softened
• 2 cups shredded mozzarella cheese, divided
• 1/2 cup grated Parmesan cheese
• Salt and freshly ground black pepper, to taste
• Optional: Red pepper flakes for extra heat

Use low-fat cream cheese for a lighter option.

Substitutions & Swaps

• Chicken can be replaced with shrimp.
• Whole milk can be substituted with 2% milk.
• Use vegan cream cheese for a dairy-free version.
• Gluten-free spaghetti is a great alternative for pasta.

How to Make It

Follow these simple steps to create your creamy Cajun chicken spaghetti:

Cook the pasta

Cook spaghetti according to package directions in salted water until al dente. Drain and set aside.

Season and cook chicken

While pasta cooks, season chicken with Cajun seasoning and smoked paprika. In a large skillet, heat olive oil over medium-high heat. Add chicken and cook until browned and cooked through, about 6–8 minutes. Remove from skillet and set aside.

Sauté garlic

In the same skillet, melt butter over medium heat. Add minced garlic and sauté for 1 minute until fragrant.

Make the roux

Sprinkle in the flour and whisk continuously for 1–2 minutes to form a roux.

Whisk in liquids

Gradually whisk in the milk and chicken broth, stirring constantly to avoid lumps. Bring to a gentle simmer.

Add cream cheese and mozzarella

Add cream cheese and 1 cup of mozzarella, stirring until melted and smooth.

Stir in Parmesan and season

Stir in Parmesan cheese and season with salt, pepper, and red pepper flakes if using.

Simmer chicken and sauce

Add cooked chicken back into the sauce and simmer for 2–3 minutes to heat through.

Combine spaghetti and sauce

Add cooked spaghetti to the skillet and toss to coat in the sauce.

Melt remaining cheese

Sprinkle remaining 1 cup mozzarella on top, cover, and let sit for 2–3 minutes until cheese melts.

Serve and garnish

Serve hot, garnished with fresh parsley or extra Parmesan if desired.

How to Store It

Fridge: Store leftovers in an airtight container for up to 3 days.
Freezer: No, as the cream-based sauce doesn’t freeze well.
Reheat: Warm in the microwave for about 2 minutes or until heated through.

Tips for Best Results

• For a spicier kick, add extra red pepper flakes while cooking.
• Make sure to thoroughly whisk the milk and broth to prevent lumps.
• Allow the covered spaghetti to rest for a few minutes before serving to enhance creaminess.
• Fresh herbs like parsley make a bright garnish and enhance flavor.

Serving Suggestions

• Pair with a side salad for a complete meal.
• Serve alongside garlic bread for a comforting dinner.
• Perfect for casual gatherings or family dinners.

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